Trauma Center: Under the Knife 2
Atlus / July 1, 2008 / Rated Teen
Data last updated July 24, 2026
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GUILT is no more. Dr. Derek Stiles and Nurse Angie Thompson faced humanity's greatest threat and triumphed. Now, in the aftermath, they find themselves in unknown territory, forced to deal with the disastrous consequences of the killer virus. Join them as they scramble to address questions left unanswered and put an end to the mystery behind the disease.
Trauma Center: Under the Knife 2 is a 2008 simulation video game developed by Vanguard for the Nintendo DS (DS), and published by Atlus. It is the fourth game in the Trauma Center series and a direct sequel to Trauma Center: Under the Knife (2005). Set three years after the events of Under the Knife, the plot follows protagonist Derek Stiles as he confronts not only the revival of terrorist organisation Delphi and its GUILT disease, but personal insecurities and corporate manipulation. The gameplay combines surgical simulation relying on the DS's touchscreen controls with a story told as a visual novel.
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